Non-antibiotics reverse resistance of bacteria to antibiotics.
- Autores: Amaral L, Kristiansen JE, Martins A, Thomsen VF, Viveiros M
- Journal: In vivo
- Link: http://www.ncbi.nlm.nih.gov/pubmed/20952744
BACKGROUND: Most clinical isolates that exhibit a multi-drug resistant phenotype owe that resistance to over-expressed efflux pumps. Compounds that are efflux pump inhibitors (EPIs) reduce or reverse resistance to antibiotics to which the bacterial strain is initially resistant. We have evaluated non-antibiotics to reduce resistance of commonly encountered bacterial pathogens to antibiotics. MATERIALS AND METHODS: […]