Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB
- Autores: Amaral L, Couto I, Dastidar S, Fanning S, Kristiansen JE, Martins A, Martins M, McCusker M, Molnar J, Pagès JM, Ramos J, Rodrigues L, Spengler G, Viveiros M
- Journal: In vivo
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Phenothiazines%2C+bacterial+efflux+pumps+and+targeting+the+macrophage+for+enhanced+killing+of+intracellular+XDRTB
Phenothiazines have their primary effects on the plasma membrane of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources, energy providing enzymes such as ATPases, and genes that regulate and code for permeability aspects of the bacterium.