GHTM

Global Health and Tropical Medicine

  • GHTM
    • Vision
    • Mission
    • Governance
    • Scientific Advisory Board
  • News
    • Outreach
    • Events
      • GHTM Sessions
      • Workshops
    • Articles
    • Jobs
  • Research
    • Cross-cutting issues
      • Global Pathogen Dispersion and Population Mobility
      • Drug Discovery and Drug Resistance
      • Diagnostics
      • Public Health Information
      • Fair Research Partnerships
    • Research Groups
      • PPS – Population health, policies and services
      • THOP – TB, HIV and opportunistic diseases and pathogens
      • VBD – Vector borne diseases and pathogens
      • IHC – Individual health care
    • Research in numbers
      • 2022
      • 2021
      • 2020
      • 2019
      • 2018
      • 2017
    • Projects
      • Ongoing Projects
      • Completed Projects
    • Members
      • Population health, policies and services
        • PPS PhD members
        • PPS non PhD members
      • TB, HIV and opportunistic diseases and pathogens
        • THOP PhD members
        • THOP non PhD members
      • Vector-borne diseases and pathogens
        • VBD PhD members
        • VBD non PhD members
      • Individual Health Care
        • IHC PhD members
        • IHC non PhD members
      • Technical / administrative support
  • Publications
    • 2023
    • 2022
  • Education
    • Master Theses
    • PhD Theses
  • Services
  • Reports
    • GHTM Reports
    • Scientific Advisory Board Reports
Home / Archives for Van Soolingen D

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

  • Autores: Alfsnes K, Balloux F, Bohlin J, Brown TS, Brynildsrud OB, Caws M, Clark T, da Silva MA, Debech N, Dunstan S, Eldholm V, Fandinho F, Feil EJ, Grandjean L, Holt KE, Kirkeleite I, Kitchen A, Lopez B, Mathema B, Monteserin J, O'Neill MB, Pepperell CS, Perdigão J, Pettersson JO, Portugal I, Ritacco V, Suffys PN, Thai PVK, Van Soolingen D, Viveiros M
  • Ano de Publicação: 2018
  • Journal: Science Advances
  • Link: http://advances.sciencemag.org/content/4/10/eaat5869

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in […]
Ler mais

Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!

  • Autores: Amaral L, Boeree MJ, Gillespie SH, Udwadia ZF, Van Soolingen D
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Thioridazine+cures+extensively+drug-resistant+tuberculosis+(XDR-TB)+and+the+need+for+global+trials+is+now

Thioridazine (TDZ) has been shown to have in vitro activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, to promote the killing of intracellular MDR and XDR strains and to cure the mouse of antibiotic-susceptible and -resistant pulmonary tuberculosis (TB) infections.
Ler mais

Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

  • Autores: Amaral L, Boeree MJ, Christensen JB, Hajos G, Kristiansen JE, Molnar J, Riedl Z, Simons SO, Van der Laan T, Van Ingen J, Van Soolingen D, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23410790

Ler mais

The added effect of thioridazine in the treatment of drug-resistant tuberculosis.

  • Autores: Abbate E, Amaral L, Udwadia Z, Van Soolingen D
  • Journal: The International Journal of Tuberculosis and Lung Disease
  • Link: http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/86433297.1/iuatld/ijtld/2012/00000016/00000012/art00026/0BD6A0E92239C33F14585566579DF2734D5804CD9C.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf

The review by Grosset et al. in a recent issue of the
Journal is highly interesting, and rightly pictures a
bright horizon for the improved treatment of tuberculosis. However, there are alternative compounds
that can already provide considerable relief in compassionate
application of treatment for multidrugr
esistant and extensively drug-resistant tuberculosis
(MDR/XDR-TB) in the short term, and may offer an
important additional effect in treatment regimens due
to a special working mechanism, such as effl ux pump
inhibition.
Ler mais

About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

Contacts

Rua da Junqueira, 100
1349-008 Lisboa
Portugal
+351 213 652 600
+351 213 632 105

  • Facebook
  • YouTube

Subscribe Newsletter

  • How to get to GHTM/IHMT
  • GHTM Sessions
  • Research Groups
  • Cross-cutting issues
© Copyright 2023 IHMT-UNL Todos os Direitos Reservados.
  • Universidade Nova de Lisboa
  • Fundação para a Ciência e a Tecnologia

    Project UID/Multi/04413/2013