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Home / Archives for Van Soolingen D

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

  • Authors: Alfsnes K, Balloux F, Bohlin J, Brown TS, Brynildsrud OB, Caws M, Clark T, da Silva MA, Debech N, Dunstan S, Eldholm V, Fandinho F, Feil EJ, Grandjean L, Holt KE, Kirkeleite I, Kitchen A, Lopez B, Mathema B, Monteserin J, O'Neill MB, Pepperell CS, Perdigão J, Pettersson JO, Portugal I, Ritacco V, Suffys PN, Thai PVK, Van Soolingen D, Viveiros M
  • Publication Year: 2018
  • Journal: Science Advances
  • Link: http://advances.sciencemag.org/content/4/10/eaat5869

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in […]
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Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now!

  • Authors: Amaral L, Boeree MJ, Gillespie SH, Udwadia ZF, Van Soolingen D
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Thioridazine+cures+extensively+drug-resistant+tuberculosis+(XDR-TB)+and+the+need+for+global+trials+is+now

Thioridazine (TDZ) has been shown to have in vitro activity against multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, to promote the killing of intracellular MDR and XDR strains and to cure the mouse of antibiotic-susceptible and -resistant pulmonary tuberculosis (TB) infections.
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Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

  • Authors: Amaral L, Boeree MJ, Christensen JB, Hajos G, Kristiansen JE, Molnar J, Riedl Z, Simons SO, Van der Laan T, Van Ingen J, Van Soolingen D, Viveiros M
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23410790

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The added effect of thioridazine in the treatment of drug-resistant tuberculosis.

  • Authors: Abbate E, Amaral L, Udwadia Z, Van Soolingen D
  • Journal: The International Journal of Tuberculosis and Lung Disease
  • Link: http://docstore.ingenta.com/cgi-bin/ds_deliver/1/u/d/ISIS/86433297.1/iuatld/ijtld/2012/00000016/00000012/art00026/0BD6A0E92239C33F14585566579DF2734D5804CD9C.pdf?link=http://www.ingentaconnect.com/error/delivery&format=pdf

The review by Grosset et al. in a recent issue of the
Journal is highly interesting, and rightly pictures a
bright horizon for the improved treatment of tuberculosis. However, there are alternative compounds
that can already provide considerable relief in compassionate
application of treatment for multidrugr
esistant and extensively drug-resistant tuberculosis
(MDR/XDR-TB) in the short term, and may offer an
important additional effect in treatment regimens due
to a special working mechanism, such as effl ux pump
inhibition.
Read More

About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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