Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation
- Autores: Alfsnes K, Balloux F, Bohlin J, Brown TS, Brynildsrud OB, Caws M, Clark T, da Silva MA, Debech N, Dunstan S, Eldholm V, Fandinho F, Feil EJ, Grandjean L, Holt KE, Kirkeleite I, Kitchen A, Lopez B, Mathema B, Monteserin J, O'Neill MB, Pepperell CS, Perdigão J, Pettersson JO, Portugal I, Ritacco V, Suffys PN, Thai PVK, Van Soolingen D, Viveiros M
- Ano de Publicação: 2018
- Journal: Science Advances
- Link: http://advances.sciencemag.org/content/4/10/eaat5869
On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in […]
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