GHTM

Global Health and Tropical Medicine

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The contribution of Institute of Hygiene and Tropical Medicine for the knowledge of infection by the Human Immunodeficiency Virus

Over the past 25 years, the Institute of Hygiene and Tropical Medicine (IHMT) has contributed significantly to the knowledge of the pathogenesis of infection by the human immunodeficiency virus (HIV). The studies cover various aspects of infection such as the characterization of the evolutionary history and genetic diversity of HIV in Portugal, and in some […]
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Cruising Venues as a Context for HIV Risky Behavior Among Men Who Have Sex With Men

We examined differences in sexual risk behaviors, HIV prevalence, and demographic characteristics between men who have sex with men (MSM) who visit different types of venues to meet sexual partners, and identified correlates of high-risk behaviors. A cross-sectional behavioral survey was conducted with a venue-based sample of 1011 MSM in Portugal. Overall, 36.3 % of MSM […]
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Donor-Recipient Identification in Para- and Poly-phyletic Trees Under Alternative HIV-1 Transmission Hypotheses Using Approximate Bayesian Computation

Diversity of the founding population of Human Immunodeficiency Virus Type 1 (HIV-1) transmissions raises many important biological, clinical, and epidemiological issues. In up to 40% of sexual infections, there is clear evidence for multiple founding variants. These variants can influence the efficacy of putative prevention methods, and the reconstruction of epidemiologic histories. The authors created an […]
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Zika virus genetic diversity and selective pressure: importance for diagnostics, vaccines and therapeutics

During the last years, an increasing number of Zika virus (ZIKV) infections has been reported in Asia and America. Due to socio-environmental factors that remain to be established, this arbovirus has explosively spread to more than 60 countries worldwide. ZIKV infections can result into severe clinical manifestations, with little knowledge available to date about how […]
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Epidemic dispersion of HIV and HCV in a population of co-infected Romanian injecting drug users

Co-infections with HIV and HCV are very frequent among people who inject drugs (PWID). However, very few studies comparatively reconstructed the transmission patterns of both viruses in the same population. We have recruited 117 co-infected PWID during a recent HIV outbreak in Romania. Phylogenetic analyses were performed on HIV and HCV sequences in order to […]
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About GHTM

GHTM is a R&D Unit that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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