GHTM

Global Health and Tropical Medicine

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Phylogenetic analysis as a forensic tool in HIV transmission investigations

HIV Phylogenetic analysis: a literature review The authors performed a literature review to analyse HIV phylogenetic analyses methods as a forensic tool. Because HIV is a fast-evolving virus, HIV genomic sequences of several individuals can be used to investigate whether they belong to a transmission network. Since the infamous ‘Florida dentist case’ in the beginning […]
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Memory B-cell depletion is a feature of HIV-2 infection even in the absence of detectable viremia.

OBJECTIVE:
Memory B-cell loss has long been recognized as an important contributor to HIV immunodeficiency. HIV-2 infection, which is characterized by a slow rate of progression to AIDS and reduced to undetectable viremia, provides a unique model to investigate B-cell disturbances.
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Resistance to antibody neutralization in HIV-2 infection occurs in late stage disease and is associated with X4 tropism.

OBJECTIVES:
To characterize the nature and dynamics of the neutralizing antibody (NAb) response and escape in chronically HIV-2 infected patients.
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About GHTM

GHTM is a R&D Unit that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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