Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Authors: Coelho TS, Couto I, Machado D, Maschmann RA, Perdigão J, Pereira C, Portugal I, Ramos DF, Rossetti MLR, Silva PA, Viveiros M, von Groll A
Publication Year: 2017
Journal: Frontiers in Microbiology
Link: https://www.frontiersin.org/articles/10.3389/fmicb.2017.00711/full

Numerous studies show efflux as a universal bacterial mechanism contributing to antibiotic resistance and also that the activity of the antibiotics subject to efflux can be enhanced by the combined use of efflux inhibitors. Nevertheless, the contribution of efflux to the overall drug resistance levels of clinical isolates of Mycobacterium tuberculosis is poorly understood and […]
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Activity of rifabutin and hemi-synthetic derivatives against Mycobacterium abscessus

BACKGROUND: Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs […]
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Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis

Activity of rifabutin and hemi-synthetic derivatives against Mycobacterium abscessus

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