In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

Authors: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
Publication Year: 2013
Journal: Malaria Journal
Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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Therapeutic efficacy of Coartem (R) for the treatment of uncomplicated malaria in Maputo, Mozambique.

Authors: Coelho L, Do Rosário V, Fernandes N, Lobo E, Nogueira F
Journal: Tropical Medicine & International Health
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=2ExAqmsJ7vIMOy1UmoG&page=1&doc=1

Authors: Cabrita E, da Cruz FP, Do Rosário VE, Gomes P, Gut J, Matos J, Moreira R, Nogueira F, Prudencio M, Rosenthal PJ
Journal: Antimicrobial Agents and Chemotherapy
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Novel+potent+metallocenes+against+liver+stage+malaria.

Novel conjugates of the antimalarial drug primaquine (compound 1) with ferrocene, named primacenes, have been synthesized and screened for their activities against blood stage and liver stage malaria in vitro and host-vector transmission in vivo.
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Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues

Authors: Barros MT, Faisca Phillips AM, Murtinheira F, Nogueira F
Publication Year: 2015
Journal: Bioorganic & Medicinal Chemistry Letters
Link: http://www.ncbi.nlm.nih.gov/pubmed/25881827

The continuous development of drug resistance by Plasmodium falciparum, the agent responsible for the most severe forms of malaria, creates the need for the development of novel drugs to fight this disease.
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Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

Authors: Arez AP, Escobar C, Lobo E, Lobo L, Nogueira F, Pateira S, Teodósio R, Varandas L, Fernandes N, Dias F
Publication Year: 2015
Journal: PLoS One
Link: http://www.ncbi.nlm.nih.gov/pubmed/25789669

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem.
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In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

Therapeutic efficacy of Coartem (R) for the treatment of uncomplicated malaria in Maputo, Mozambique.

Novel potent metallocenes against liver stage malaria

Synthesis and antimalarial evaluation of prodrugs of novel fosmidomycin analogues

Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique after the Introduction of the ACTs

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