The effect of primary drug resistance on CD4 cell decline and the viral load set-point in HIV-positive individuals before the start of antiretroviral therapy

Authors: Schultze A, Torti C, Cozzi-Lepri A, Vandamme AM, Zazzi M, Sambatakou H, De Luca A, Geretti AM, Sönnerborg A, Ruiz L, Monno L, Di Giambenedetto S, Gori A, Lapadula G
Publication Year: 2019
Journal: AIDS
Link: https://www.ncbi.nlm.nih.gov/pubmed/30325769

OBJECTIVE: To evaluate the effect of primary resistance and selected polymorphic amino-acid substitutions in HIV reverse transcriptase and protease on the CD4 cell count and viral load set point before the start of antiretroviral treatment. DESIGN: Prospective cohort study. METHODS: A total of 6180 individuals with a resistance test prior to starting antiretroviral treatment accessing […]
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Antimicrobial resistance and molecular characteristics of Neisseria gonorrhoeae isolates from men who have sex with men

Authors: Calado J, Castro R, Lopes A, Campos MJ, Rocha M, Pereira F
Publication Year: 2019
Journal: International Journal of Infectious Diseases
Link: https://www.researchgate.net/publication/328766979_Antimicrobial_resistance_and_molecular_characteristics_of_Neisseria_gonorrhoeae_isolates_from_MSM

Objectives: To analyze the susceptibility of Neisseria gonorrhoeae isolates to penicillin (Pen), cefixime (Cfm), ceftriaxone (Cro), tetracycline (Tet), ciprofloxacin (Cip), azithromycin (Azm) and spectinomycin (Spt). To verify the presence of Mutations in resistant genes. Methods: Antibiotic susceptibility testing was carried out by Etest method in 30 N. gonorrhoeae isolates collected from MSM population. PCR and […]
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Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Authors: Alfsnes K, Balloux F, Bohlin J, Brown TS, Brynildsrud OB, Caws M, Clark T, da Silva MA, Debech N, Dunstan S, Eldholm V, Fandinho F, Feil EJ, Grandjean L, Holt KE, Kirkeleite I, Kitchen A, Lopez B, Mathema B, Monteserin J, O'Neill MB, Pepperell CS, Perdigão J, Pettersson JO, Portugal I, Ritacco V, Suffys PN, Thai PVK, Van Soolingen D, Viveiros M
Publication Year: 2018
Journal: Science Advances
Link: http://advances.sciencemag.org/content/4/10/eaat5869

On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely dominated by historical migrations out of Europe. We demonstrate an intimate temporal relationship between European colonial expansion into Africa and the Americas and the spread of L4 tuberculosis (TB). Markedly, in […]
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Time to harmonize dengue nomenclature and classification

Authors: Alcantara LCJ, Cuypers L, Libin PJK, Muñoz-Jordán J, Nowé A, Santiago GA, Simmonds P, Theys K, Vandamme AM
Publication Year: 2018
Journal: Viruses
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213058/

Dengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus’s ongoing global spread. Persistent […]
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Assessment of a Brazilian public policy intervention to address schistosomiasis in Pernambuco state: The SANAR program, 2011-2014

Authors: da Silva JAM, da Silva Junior JB, Facchini LA, Felisberto E, Nunes BP, Tomasi E
Publication Year: 2018
Journal: BMC Public Health
Link: https://www.ncbi.nlm.nih.gov/pubmed/30359232

BACKGROUND: Brazil is an endemic country for schistosomiasis in the Latin American and Caribbean countries. Pernambuco is a higher-endemic Brazilian state among the 19 states reporting the disease in the country; schistosomiasis affects 102 (55%) of its 185 municipalities. Our objective was to evaluate the effectiveness of the treatment cycles of the SANAR Program (Plan […]
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The effect of primary drug resistance on CD4 cell decline and the viral load set-point in HIV-positive individuals before the start of antiretroviral therapy

Antimicrobial resistance and molecular characteristics of Neisseria gonorrhoeae isolates from men who have sex with men

Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation

Time to harmonize dengue nomenclature and classification

Assessment of a Brazilian public policy intervention to address schistosomiasis in Pernambuco state: The SANAR program, 2011-2014

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