GHTM

Global Health and Tropical Medicine

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Home / Publications

Hemozoin activates the innate immune system and reduces Plasmodium berghei infection in Anopheles gambiae

  • Authors: Gonçalves L, Silveira H, Simoes ML
  • Publication Year: 2015
  • Journal: Parasites & Vectors
  • Link: https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-014-0619-y

Malaria is a worldwide infectious disease caused by Plasmodium parasites and transmitted by female Anopheles mosquitoes. The malaria vector mosquito Anophelescan trigger effective mechanisms to control completion of the Plasmodium lifecycle; the mosquito immune response to the parasite involves several pathways which are not yet well characterized. Plasmodium metabolite hemozoin has emerged as a potent immunostimulator of mammalian tissues. In this study, we aim […]
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Pulmonary tuberculosis in Sao Luis, State of Maranhao, Brazil: space and space-time risk clusters for death (2008-2012)

  • Authors: Arcêncio RA, Chiaravalloti Neto F, Fronteira I, Garcia MC, Popolin MP, Rodrigues LB, Santos Neto M, Yamamura M
  • Publication Year: 2015
  • Journal: Revista da Sociedade Brasileira de Medicina Tropical
  • Link: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000100069

The objective was to identify space and space-time risk clusters for the occurrence of deaths in a priority city for the control of tuberculosis (TB) in the Brazilian Northeast. Ecological research was undertaken in the City of São Luis/Maranhão. Cases were considered that resulted in deaths in the population living in the urban region of […]
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Re-Thinking Pharmaceutical Production in Africa; Insights from the Analysis of the Local Manufacturing Dynamics in Mozambique and Zimbabwe

  • Authors: Banda G, Russo G
  • Publication Year: 2015
  • Journal: Studies in Comparative International Development
  • Link: http://link.springer.com/article/10.1007%2Fs12116-015-9186-2

Until recently, consensus existed in certain circles that the African industry was not suitable for cost-effective production of quality, safe drugs. Yet, public and private pharmaceutical enterprises have cropped up on the continent, with some venturing into production of sophisticated and complex drugs, such as antiretrovirals (ARVs). In our study, we analyse and contrast the […]
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Exposure to Leishmania spp. and sand flies in domestic animals in northwestern Ethiopia

  • Authors: Baneth G, Hailu A, Jaffe CL, Kassahun A, King R, Kostalova T, Lestinova T, Maia C, Polanska N, Rohousova I, Talmi-Frank D, Volf P, Votypka J, Warburg A, Yasur-Landau D
  • Publication Year: 2015
  • Journal: Parasites & Vectors
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26152578

BACKGROUND: Human visceral leishmaniasis caused by Leishmania donovani is considered an anthroponosis; however, Leishmania-infected animals have been increasingly reported in L. donovani foci, and the role of these animals as reservoirs for human L. donovani infection remains unclear. METHODS: We conducted a study of domestic animals (goats, sheep, cows, dogs, and donkeys) in three L. […]
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Measuring efflux and permeability in mycobacteria

  • Authors: Ainsa JA, Rodrigues L, Viveiros M
  • Publication Year: 2015
  • Journal: Mycobacteria Protocols, pp 227-239, part of the book series, Methods in Molecular Biology, 1285
  • Link: https://link.springer.com/protocol/10.1007/978-1-4939-2450-9_13

http://www.ncbi.nlm.nih.gov/pubmed/25779319
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025

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