Chemotherapy for second-stage Human African trypanosomiasis

Authors: Kennedy A, Lutje V, Seixas J
Journal: Cochrane Database of Systematic Reviews
Link: http://www.ncbi.nlm.nih.gov/pubmed/20687080

BACKGROUND: Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease affecting people in the poorest parts of Africa and is fatal without treatment. Few drugs are currently available for second-stage sleeping sickness, with considerable adverse events and variable efficacy. OBJECTIVES: To evaluate the effectiveness and safety of drugs for treating second-stage human […]
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Differentiation of Cryptococcus neoformans varieties and Cryptococcus gattii using CAP59-based loop-mediated isothermal DNA amplification.

Members of the Cryptococcus species complex (C. neoformans and C. gattii) are opportunistic pathogens responsible for frequently fatal cases of meningoencephalitis. These yeasts have been classified into five serotypes. Serotypes A and D are assigned to C. neoformans var. grubii and C. neoformans var. neoformans, respectively, Serotype AD strains are hybrids and serotype B and […]
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Potential threat of malaria epidemics in a low transmission area, as exemplified by São Tomé and Príncipe

Authors: Do Rosário VE, Lee PW, Liu CT, Rampao HS, Shaio MF
Journal: Malaria Journal
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Potential+threat+of+malaria+epidemics+in+a+low+transmission+area%2C+as+exemplified+by+S%C3%A3o+Tom%C3%A9+and+Pr%C3%ADncipe

BACKGROUND: Plasmodium falciparum is the major cause of malaria infection in the island of São Tomé, in the Republic of São Tomé and Príncipe (STP), with an incidence of 40 – 50% before 2004. Since 2004, through the coordination of the Ministry of Health of STP and their Centro Nacional de Endemias (CNE), an integrated […]
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Bis-alkylamine quindolone derivatives as new antimalarial leads

Authors: Figueiredo P, Gani K, Gut J, Lavrado J, Lopes D, Moreira R, Nobre PA, Paulo A, Rosário VD, Rosenthal PJ, Santos SA
Journal: Bioorganic & Medicinal Chemistry Letters
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Bis-alkylamine+quindolone+derivatives+as+new+antimalarial+leads

Quindolone derivatives, designed to target the malaria parasite digestive vacuole and heme detoxification pathway, have been synthesized by reaction with 2-chloro-N,N-diethylethanamine. This reaction gave N,O-, N,N- and O-alkylated products containing one or two basic side-chains. The compounds were evaluated for antiplasmodial activity against the chloroquine-resistant Plasmodium falciparum W2 strain and for cytotoxicity in HepG2 A16 […]
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Developing an IT Governance Framework at Hospital Sao Sebastiao

Authors: Lapão LV
Journal: ECISM
Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=1&SID=W1wrr3wkoT6pUvoX9hM&page=1&doc=1

This paper describes the introduction of an IT Governance Framework into a Hospital environment. It further addresses the relationship between corporate governance (hospital strategy and organization) and the role of IT Governance in managing new services deployment. Both ITIL and COBIT are introduced as a best practice for supporting Hospital Information Systems (HIS) management. IT […]
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Chemotherapy for second-stage Human African trypanosomiasis

Differentiation of Cryptococcus neoformans varieties and Cryptococcus gattii using CAP59-based loop-mediated isothermal DNA amplification.

Potential threat of malaria epidemics in a low transmission area, as exemplified by São Tomé and Príncipe

Bis-alkylamine quindolone derivatives as new antimalarial leads

Developing an IT Governance Framework at Hospital Sao Sebastiao

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