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Home / Archives for Vaccine

CYTED Network to develop an immunogen compatible with integrated management strategies for tick control in cattle

  • Autores: Anadón JLC, Bechara GH, Cruz RL, Domingos A, Machado RZ, Pérez AAL, Rodríguez-Mallon A, Tamayo Sosa AR
  • Ano de Publicação: 2018
  • Journal: Vaccine
  • Link: https://www.sciencedirect.com/science/article/pii/S0264410X18313409?dgcid=rss_sd_all

INCOGARR is a thematic network recently approved to be financially supported by the Ibero-American Program of Science and Technology for Development (CYTED). The objectives of this Network are the design and evaluation of an efficient and feasible anti-tick vaccine candidate from the technical and economical points of view and also sharing experiences in the immunological […]
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Early impact of rotavirus vaccination in children less than five years of age in Mozambique

  • Autores: Anapakala E, Bambo M, Bero DM, Cassocera M, Chilaúle JJ, Chissaque A, Cossa-Moiane I, de Deus N, Guimarães EL, João ED, Langa JS, Mwenda JM, Parashar UD, Sambo J, Sitoe E, Tate JE, Weldegebriel GG
  • Ano de Publicação: 2017
  • Journal: Vaccine
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/?term=Bero%20DM%5BAuthor%5D&cauthor=true&cauthor_uid=29128381

Mozambique introduced rotavirus vaccine (Rotarix, GSK Biologicals) in the National Immunization Program in September 2015 with the objective of reducing the burden of total diarrheal disease and specifically severe rotavirus disease. This study aimed to evaluate the early impact of rotavirus vaccine in reducing all-cause diarrhea and rotavirus-specific hospitalizations. We analysed stool specimens collected from […]
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Vaccination with proteins involved in tick-pathogen interactions reduces vector infestations and pathogen infection

  • Autores: Antunes S, de la Fuente J, Domingos A, Merino O, Moreno-Cid JA, Mosqueda J, Perez de la Lastra JM, Rodríguez S, Rosario-Cruz R
  • Ano de Publicação: 2013
  • Journal: Vaccine
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24084474

Tick-borne pathogens cause diseases that greatly impact animal health and production worldwide. The ultimate goal of tick vaccines is to protect against tick-borne diseases through the control of vector infestations and reducing pathogen infection and transmission. Tick genetic traits are involved in vector-pathogen interactions and some of these molecules such as Subolesin (SUB) have been shown to protect against vector infestations and pathogen infection.
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Lesser protein degradation machinery correlates with higher BM86 tick vac- cine efficacy in Rhipicephalus annulatus when compared to Rhipicephalus micro-plus

  • Autores: Almazán C, de Mera IGF, del Valle M, Marina A, Mateos-Hernández L, Popara M, Villar M, Domingos A
  • Journal: Vaccine
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23973246

Infestations with cattle ticks, Rhipicephalus (Boophilus) microplus and Rhipicephalus annulatus, economically impact cattle production in tropical and subtropical regions of the world. Vaccines containing the recombinant R. microplus BM86 gut antigen were developed and commercialized to induce an immunological protection in cattle against tick infestations. These vaccines demonstrated that tick control by vaccination is cost-effective, reduces environmental contamination and prevents the selection of drug resistant ticks that result from repeated acaricide applications.
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Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells

  • Autores: Alexandre-Pires G, Carreira J, Carvalho S, Rodrigues A, Santos-Gomes GM, Teixeira F
  • Ano de Publicação: 2014
  • Journal: Vaccine
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24486368

Control of zoonotic visceral leishmaniosis can be achieved using several available drugs. These drugs present high toxicity and require longer treatment regimens which complicate compliance to the treatment. Other control measures directed to the vector or the reservoirs are useful tools to restrain the spreading of this disease but the effects are transitory.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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