GHTM

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Home / Archives for Santos-Gomes GM

Canine leishmaniosis. Modulation of macrophage/lymphocyte interactions by L. infantum.

  • Authors: Alexandre-Pires G, Cartaxeiro C, da Fonseca IP, de Brito TV, Diaz S, Martins C, Rodrigues A, Santos-Gomes GM, Silva MJ
  • Journal: Veterinary Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Canine+leishmaniosis.+Modulation+of+macrophage%2Flymphocyte+interactions+by+L.+infantum.

Canine leishmaniosis, caused by Leishmania infantum, is a systemic disease with variable clinical signs and a progressive evolution. This disease is characterized by impaired T cell-mediated immune response, which has been associated with disease chronicity and high mortality. Protective immunity against leishmaniosis is thought to be mediated by T cell and cytokine production.
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Cytokine Gene Expression in the Tissues of Dogs Infected by Leishmania infantum

  • Authors: Alexandre-Pires G, Alves LC, Barbosa AMG, da Fonseca IP, de Brito TV, Marques C, Rodrigues OR, Santos-Gomes GM, Soares-Clemente M
  • Journal: Journal of Comparative Pathology
  • Link: https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=21&SID=P2WA5hwy5j35Sqjoq2z&page=1&doc=1

Canine leishmaniosis (CanL) caused by the protozoan parasite Leishmania infantum is a chronic systemic disease that is endemic in certain parts of the world. The domestic dog is the most important reservoir of L. infantum and is the main source of infection for other animals and for the human population.
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Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells

  • Authors: Alexandre-Pires G, Carreira J, Carvalho S, Rodrigues A, Santos-Gomes GM, Teixeira F
  • Publication Year: 2014
  • Journal: Vaccine
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24486368

Control of zoonotic visceral leishmaniosis can be achieved using several available drugs. These drugs present high toxicity and require longer treatment regimens which complicate compliance to the treatment. Other control measures directed to the vector or the reservoirs are useful tools to restrain the spreading of this disease but the effects are transitory.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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