A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

Authors: Alexiev I, Balotta C, Debaisieux L, Devaux C, Fransen K, García Ribas S, Gomes P, Incardona F, Kaiser R, Lemey P, Paraschiv S, Paredes R, Peeters M, Pineda-Peña AC, Ruelle J, Sayan M, Sönnerborg A, Van den Wijngaert S, Van Laethem K, Van Ranst M, Vancutsem E, Vandamme AM, Verhofstede C, Vinken L
Publication Year: 2017
Journal: Virus Evolution
Link: https://academic.oup.com/ve/article/3/suppl_1/vew036.020/4090767%20

HIV-1 non-B subtype infections have been observed in Belgium since the 1980s. However, subtype B predominates amongst men having sex with men (MSM), whereas other subtypes are mainly associated with sub-Saharan African migrants and heterosexual risk behavior. In the last decade, subtype F1 diagnoses have increased substantially in Belgium, representing 9% of newly diagnosed and […]
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Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

Authors: Aragri M, Balog D, Ceccherini-Silberstein F, Cento V, Cuypers L, Di Maio VC, Fabeni L, Focà A, Marascio N, Nevens F, Perno CF, Pineda-Peña AC, Schrooten Y, Torti C, Van Laethem K, Vandamme AM, Vrancken B
Publication Year: 2017
Journal: BMC Evolutionary Biology
Link: https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-017-0913-3

In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic […]
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Large cluster outbreaks sustain the HIV epidemic among MSM in Quebec

Authors: Brenner BG, Grossman Z, Hardy I, Ibanescu RI, Moodie E, Otis J, Roger M, Stephens D, Vandamme AM, Wainberg MA
Publication Year: 2017
Journal: AIDS
Link: https://insights.ovid.com/crossref?an=00002030-201703130-00012you

Objective: HIV-1 epidemics among men having sex with men (MSM) remain unchecked despite advances in treatment and prevention paradigms. This study combined viral phylogenetic and behavioural risk data to better understand underlying factors governing the temporal growth of the HIV epidemic among MSM in Quebec (2002-2015). Methods: Phylogenetic analysis of pol sequences was used to […]
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Phylogenetic evidence for underreporting of male-to-male sex among human immunodeficiency virus–infected donors in the Netherlands and Flanders

Authors: Bezemer D, Claas EC, Compernolle V, de Smet A, van de Laar TJ, Van Laethem K, van Sighem AI, Van Wijngaerden E, Vandamme AM, Vandewalle G, Zaaijer HL
Publication Year: 2017
Journal: Transfusion
Link: https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.14097

Separate transmission networks for human immunodeficiency virus (HIV) coexist. Molecular typing of viral genomes can provide insight in HIV transmission routes in donors for whom risk behavior-based donor selection failed. This study includes all HIV-infected Dutch and Flemish donors in the period 2005 to 2014 (n = 55). Part of the HIV polymerase (pol) gene was amplified, […]
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PhyloGeoTool: interactively exploring large phylogenies in an epidemiological context

Authors: Baele G, Bezenchek A, EucoHIV Study Group, Incardona F, Libin P, Nowé A, Sönnerborg A, Theys K, Vandamme AM, Vanden Eynden E
Publication Year: 2017
Journal: Bioinformatics
Link: https://www.ncbi.nlm.nih.gov/pubmed/28961923

MOTIVATION: Clinicians, health officials and researchers are interested in the epidemic spread of pathogens in both space and time to support the optimization of intervention measures and public health policies. Large sequence databases of virus sequences provide an interesting opportunity to study this spread through phylogenetic analysis. To infer knowledge from large phylogenetic trees, potentially […]
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A21 HIV-1 sub-subtype F1 outbreak among MSM in Belgium

Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

Large cluster outbreaks sustain the HIV epidemic among MSM in Quebec

Phylogenetic evidence for underreporting of male-to-male sex among human immunodeficiency virus–infected donors in the Netherlands and Flanders

PhyloGeoTool: interactively exploring large phylogenies in an epidemiological context

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