Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis.

Authors: Amaral L, Handzlik J, Kiec-Kononowicz K, Molnar J, Ocsovszki I, Spengler G, Viveiros M
Journal: Anticancer Research
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Modulation+of+multidrug+efflux+pump+activity+by+new+hydantoin+derivatives+on+colon+adenocarcinoma+cells+without+inducing+apoptosis

BACKGROUND:
Hydantoin derivatives are very promising candidates to improve the efficacy of anticancer chemotherapy. Previously, we demonstrated that eight hydantoin derivatives inhibited the P-glycoprotein (ABCB1) efflux pump of mouse T-lymphoma cells, as well as acting synergistically with the anticancer drug doxorubicin.
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Inhibition of efflux pumps in methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina.

Six cucurbitane-type triterpenoids (1-6) isolated from the aerial parts of Momordica balsamina were evaluated for their ability to inhibit the activity of bacterial efflux pumps of methicillin-resistant Staphylococcus aureus (MRSA) COL(OXA), Enterococcus faecalis ATCC 29212, Salmonella enterica subsp.
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Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

Authors: Amaral L, Armada A, Handzlik J, Kiec-Kononowicz K, Martins A, Molnar J, Spengler G
Journal: Anticancer Research
Link: http://www.ncbi.nlm.nih.gov/pubmed/22753759

Bacteria and cancer cells frequently increase their resistance to chemotherapeutics as a consequence of therapy. Whenever studied, refractory response to chemotherapy is due to the over-expression of efflux pumps that render the bacterium or cancer cell resistant not only to the agent used for therapy, but to many, if not all other agents as well.
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Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines

Authors: Amaral L, Cerca P, Couto I, Fanning S, Machado L, Martins A, Pagès JM, Spengler G, Viveiros M
Journal: International Journal of Antimicrobial Agents
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ethidium+bromide+efflux+by+Salmonella%3A+modulation+by+metabolic+energy%2C+pH%2C+ions+and+phenothiazines

The main efflux pump of Salmonella enterica serotype Enteritidis, which obtains its energy for the extrusion of noxious agents from the proton-motive force, was studied with the aid of an ethidium bromide (EtBr) semi-automated method under conditions that define the role of metabolic energy, ions and pH in the extrusion of the universal substrate EtBr.
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Modulation of multidrug efflux pump activity by new hydantoin derivatives on colon adenocarcinoma cells without inducing apoptosis.

Inhibition of efflux pumps in methicillin-resistant Staphylococcus aureus and Enterococcus faecalis resistant strains by triterpenoids from Momordica balsamina.

Inhibitors of bacterial efflux pumps that also inhibit efflux pumps of cancer cells.

Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines

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