An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

Authors: Azzali E, Coelho T, Costa SS, Couto I, da Silva PEA, Lopes E, Machado D, Pieroni M, Viveiros M
Publication Year: 2016
Journal: ASSAY and Drug Development Technologies
Link: https://www.liebertpub.com/doi/pdf/10.1089/adt.2016.752

Infections caused by Mycobacterium tuberculosis and other mycobacteria are major challenges for global public health. Particularly worrisome are infections caused by multidrug-resistant bacteria, which are increasingly difficult to treat because of the loss of efficacy of the current antibacterial agents, a problem that continues to escalate worldwide. There has been a limited interest and investment […]
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Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy

Authors: Azzali E, Costa SS, Costantino G, Couto I, Machado D, Pieroni M, Viveiros M
Publication Year: 2015
Journal: Journal of Medicinal Chemistry
Link: https://pubs.acs.org/doi/10.1021/acs.jmedchem.5b00428

Tuberculosis, caused by Mycobacterium tuberculosis, is still one of the leading infectious diseases globally. Therefore, novel approaches are needed to face this disease. Efflux pumps are known to contribute to the emergence of M. tuberculosis drug resistance. Thioridazine has shown good anti-TB properties both in vitro and in vivo, likely due to its capacity to […]
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Spectinamides: a challenge, a proof, and a suggestion

Authors: Pieroni M, Viveiros M
Publication Year: 2014
Journal: Trends in Microbiology
Link: http://www.ncbi.nlm.nih.gov/pubmed/24636244

New drugs and shorter regimens are needed to fight resistant forms of tuberculosis. Screening of chemical libraries for mining hit compounds is the common approach to find new antituberculars. A new medicinal chemistry and biology directed research rational has recently been successfully described by Lee and coworkers in Nature Medicine.
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An Experimental Model for the Rapid Screening of Compounds with Potential Use Against Mycobacteria

Rational Design and Synthesis of Thioridazine Analogues as Enhancers of the Antituberculosis Therapy

Spectinamides: a challenge, a proof, and a suggestion

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