Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates

• Authors: Jaciara de Lourdes do Carmo Guimarães Diniz, Andrea von Groll, Gisela Unis, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti, Júlia Silveira Vianna, Daniela Fernandes Ramos, Ana Júlia Reis, Priscila Cristina Bartolomeu Halicki, João Luis Rheingantz Scaini, Yasmin Castillos de Ibrahim das Neves, Jody Phelan, Ana Rita Gomes, Susana Campino, Karina dos Santos Machado, Adriano Velasque Werhli, Arnab Pain, Taane Gregory Clark, João Perdigão, Miguel Viveiros, Isabel Portugal, Pedro Eduardo Almeida Silva
• Publication Year: 2021
• Journal: Tuberculosis, vol 131, art 102137
• Link: https://doi.org/10.1016/j.tube.2021.102137

ABSTRACT Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously […]
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