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Home / Archives for Susana Campino

Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates

  • Autores: Jaciara de Lourdes do Carmo Guimarães Diniz, Andrea von Groll, Gisela Unis, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti, Júlia Silveira Vianna, Daniela Fernandes Ramos, Ana Júlia Reis, Priscila Cristina Bartolomeu Halicki, João Luis Rheingantz Scaini, Yasmin Castillos de Ibrahim das Neves, Jody Phelan, Ana Rita Gomes, Susana Campino, Karina dos Santos Machado, Adriano Velasque Werhli, Arnab Pain, Taane Gregory Clark, João Perdigão, Miguel Viveiros, Isabel Portugal, Pedro Eduardo Almeida Silva
  • Ano de Publicação: 2021
  • Journal: Tuberculosis, vol 131, art 102137
  • Link: https://doi.org/10.1016/j.tube.2021.102137

ABSTRACT Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously […]
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Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid

  • Autores: Paula J. Gómez‑González, João Perdigão, Pedro Gomes, Zully M. Puyen, David Santos‑Lazaro, Gary Napier, Martin L. Hibberd, Miguel Viveiros, Isabel Portugal, Susana Campino, Jody E. Phelan, Taane G. Clark
  • Ano de Publicação: 2021
  • Journal: Scientific Reports, 11, art 19431
  • Link: https://doi.org/10.1038/s41598-021-98862-4

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious diseases worldwide. Multidrug and extensively drug‑resistant strains are making disease control difficult, and exhausting treatment options. New anti‑TB drugs bedaquiline (BDQ), delamanid (DLM) and pretomanid (PTM) have been approved for the treatment of multi‑drug resistant TB, but there is increasing resistance to […]
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Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique

  • Autores: André Silva-Pinto, João Domingos, Margarida Cardoso, Ana Reis, Ernest Diez Benavente, João Paulo Caldas, Cláudia Conceição, Cristina Toscano, Teresa Baptista-Fernandes, Taane G. Clark, Kamal Mansinho, Susana Campino, Fatima Nogueira
  • Ano de Publicação: 2021
  • Journal: International Journal of Infectious Diseases
  • Link: https://www.sciencedirect.com/science/article/pii/S1201971221005634?via%3Dihub

Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique   Highlights Artemether-lumefantrine (AL) treatment failure of imported malaria in Portugal AL treatment failure in the presence of wild-type pfk13 and pfmdr1 Is the standard 3-day course of AL sufficient to ensure parasite clearance? AL increasing treatment failures urges closer […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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