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Home / Archives for Miguel Viveiros

Whole-genome sequencing as a tool for studying the microevolution of drug-resistant serial Mycobacterium tuberculosis isolates

  • Authors: Jaciara de Lourdes do Carmo Guimarães Diniz, Andrea von Groll, Gisela Unis, Elis Regina Dalla Costa, Maria Lucia Rosa Rossetti, Júlia Silveira Vianna, Daniela Fernandes Ramos, Ana Júlia Reis, Priscila Cristina Bartolomeu Halicki, João Luis Rheingantz Scaini, Yasmin Castillos de Ibrahim das Neves, Jody Phelan, Ana Rita Gomes, Susana Campino, Karina dos Santos Machado, Adriano Velasque Werhli, Arnab Pain, Taane Gregory Clark, João Perdigão, Miguel Viveiros, Isabel Portugal, Pedro Eduardo Almeida Silva
  • Publication Year: 2021
  • Journal: Tuberculosis, vol 131, art 102137
  • Link: https://doi.org/10.1016/j.tube.2021.102137

ABSTRACT Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously […]
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HIV and Tuberculosis Co-Infection Among Migrants in Portugal: A Brief Study on Their Sociodemographic, Clinical, and Genomic Characteristics

  • Authors: Ana Maria Tavares, Marta Pingarilho, Judite Batista, Miguel Viveiros, Sónia Dias, Cristina Toscano, Perpetua Gomes, Ana Abecasis
  • Publication Year: 2021
  • Journal: AIDS Research and Human Retroviruses, 37(1), pp 34–37
  • Link: https://doi.org/10.1089/aid.2020.0119

SHORT COMMUNICATION ABSTRACT HIV and tuberculosis (TB) are among the global deadliest diseases. Migrant populations are particularly vulnerable to these infections. Yet, literature is still scarce on the epidemiology of HIV–TB co-infection among migrants. In this study, we characterized native and migrant HIV patients followed in Portuguese hospitals, who were diagnosed with TB, regarding their […]
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Multicentre testing of the EUCAST broth microdilution reference method for MIC determination on Mycobacterium tuberculosis

  • Authors: Thomas Schön, Jim Werngren, Diana Machado, Emanuele Borroni, Maria Wijkander, Gerard Lina, Johan Mouton, Erika Matuschek, Gunnar Kahlmeter, Christian Giske, Miguel Santin, Daniela Maria Cirillo, Miguel Viveiros, Emmanuelle Cambau
  • Publication Year: 2021
  • Journal: Clinical Microbiology and Infection, 27(2), pp 288.e1 - 288.e4
  • Link: https://doi.org/10.1016/j.cmi.2020.10.019

ABSTRACT ‘Objectives:’ The first objective of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) subcommittee for antimycobacterial susceptibility testing (AMST), launched in 2016, was to set a reference method for determining the MICs of antituberculous agents, since many protocols are used worldwide and a consensus one is needed for the determination of microbiological breakpoints. ‘Methods:’ […]
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Genomic-based surveillance reveals high ongoing transmission of multi-drug-resistant Mycobacterium tuberculosis in Southern Brazil

  • Authors: Richard Steiner Salvato, Ana Júlia Reis, Sun Hee Schiefelbein, Michael Andrés Abril Gómez, Stéphanie Steiner Salvato, Larissa Vitória da Silva, Elis Regina Dalla Costa, Gisela Unis, Claudia Fontoura Dias, Miguel Viveiros, Isabel Portugal, Andrea von Groll, Pedro Eduardo Almeida da Silva, Afrânio Lineu Kritski, João Perdigão, Maria Lucia Rosa Rossetti
  • Publication Year: 2021
  • Journal: International Journal of Antimicrobial Agents, 58(4), art 106401
  • Link: https://doi.org/10.1016/j.ijantimicag.2021.106401

HIGHLIGHTS • Disputed mutations were found in 21.9% of strains resistant to isoniazid alone, evidencing underestimation of multi-drug resistance. • 73.4% of multi-drug-resistant cases were linked to ongoing transmission events. • Intracluster acquisition of novel drug-resistance mutations was found, revealing important amplification of resistance. ABSTRACT Genomic-based surveillance on the occurrence of drug resistance and its […]
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Genetic diversity of candidate loci linked to Mycobacterium tuberculosis resistance to bedaquiline, delamanid and pretomanid

  • Authors: Paula J. Gómez‑González, João Perdigão, Pedro Gomes, Zully M. Puyen, David Santos‑Lazaro, Gary Napier, Martin L. Hibberd, Miguel Viveiros, Isabel Portugal, Susana Campino, Jody E. Phelan, Taane G. Clark
  • Publication Year: 2021
  • Journal: Scientific Reports, 11, art 19431
  • Link: https://doi.org/10.1038/s41598-021-98862-4

ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the deadliest infectious diseases worldwide. Multidrug and extensively drug‑resistant strains are making disease control difficult, and exhausting treatment options. New anti‑TB drugs bedaquiline (BDQ), delamanid (DLM) and pretomanid (PTM) have been approved for the treatment of multi‑drug resistant TB, but there is increasing resistance to […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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