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Home / Archives for Latino DARS

Synthesis and Biological Evaluation of Hybrid 1,5- and 2,5-Disubstituted Indoles as Potentially New Antitubercular Agents

  • Autores: Aires-de-Sousa J, Estevao MS, Kovalishyn V, Latino DARS, Marques MMB, Martins F, Ramos J, Soares A, Viveiros M
  • Ano de Publicação: 2017
  • Journal: Medicinal Chemistry
  • Link: http://www.eurekaselect.com/149956/article%20

Tuberculosis (TB) is the second leading cause of mortality worldwide being a highly contagious and insidious illness caused by Mycobacterium tuberculosis, Mtb. Additionally, the emergence of multidrug-resistant and extensively drug-resistant strains of Mtb, together with significant levels of co-infection with HIV and TB (HIV/TB) make the search for new antitubercular drugs urgent and challenging. This […]
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Design, synthesis and biological evaluation of novel isoniazid derivatives with potent antitubercular activity

  • Autores: Aires-de-Sousa J, Correia HE, Elvas-Leitao R, Kovalishyn V, Latino DARS, Martins F, Miranda V, Ramos J, Reis M, Santos L, Santos S, Ventura C, Vitorino S, Viveiros M
  • Ano de Publicação: 2014
  • Journal: European Journal of Medicinal Chemistry
  • Link: http://www.sciencedirect.com/science/article/pii/S0223523414004061

The disturbing emergence of multidrug-resistant strains of Mycobacterium tuberculosis(Mtb) has been driving the scientific community to urgently search for new and efficient antitubercular drugs. Despite the various drugs currently under evaluation, isoniazid is still the key and most effective component in all multi-therapeutic regimens recommended by the WHO. This paper describes the QSAR-oriented design, synthesis and in vitro antitubercular activity of several potent isoniazid derivatives (isonicotinoyl hydrazones and isonicotinoyl hydrazides) against H37Rv and two resistant Mtb strains.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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