Synthesis and Biological Evaluation of Hybrid 1,5- and 2,5-Disubstituted Indoles as Potentially New Antitubercular Agents

• Autores: Aires-de-Sousa J, Estevao MS, Kovalishyn V, Latino DARS, Marques MMB, Martins F, Ramos J, Soares A, Viveiros M
• Ano de Publicação: 2017
• Journal: Medicinal Chemistry
• Link: http://www.eurekaselect.com/149956/article%20

Tuberculosis (TB) is the second leading cause of mortality worldwide being a highly contagious and insidious illness caused by Mycobacterium tuberculosis, Mtb. Additionally, the emergence of multidrug-resistant and extensively drug-resistant strains of Mtb, together with significant levels of co-infection with HIV and TB (HIV/TB) make the search for new antitubercular drugs urgent and challenging. This […]
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