Host determinants of infectiousness in smear-positive patients with pulmonary tuberculosis

Background Epidemiologic data suggests that only a minority of tuberculosis (TB) patients are infectious. Cough aerosol sampling is a novel quantitative method to measure TB infectiousness. Methods We analyzed data from three studies conducted in Uganda and Brazil over a 13-year period. We included sputum acid fast bacilli (AFB) and culture positive pulmonary TB patients […]
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Cough-aerosol cultures of Mycobacterium tuberculosis in the prediction of outcomes after exposure. A household contact study in Brazil

Authors: Acuña-Villaorduña C, Dietze R, Ellner JJ, Fennelly KP, Gaeddert M, Hadad DJ, Jones-López EC, Marques-Rodrigues P, Palaci M, Schmidt-Castellani LG, White LF
Publication Year: 2018
Journal: PLoS One
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206384

Background Mycobacterium tuberculosis cultures of cough-generated aerosols from patients with pulmonary tuberculosis (TB) are a quantitative method to measure infectiousness and to predict secondary outcomes in exposed contacts. However, their reproducibility has not been established. Objective To evaluate the predictive value of colony-forming units (CFU) of M. tuberculosis in cough aerosols on secondary infection and disease in household contacts […]
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Host determinants of infectiousness in smear-positive patients with pulmonary tuberculosis

Cough-aerosol cultures of Mycobacterium tuberculosis in the prediction of outcomes after exposure. A household contact study in Brazil

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