GHTM

Global Health and Tropical Medicine

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Home / Publications

Ten years since the 2008 introduction of dental vouchers in the Portuguese NHS

  • Authors: Simões J, Figueiredo Augusto G, do Céu A, Ferreira MC, Jordão M, Calado R, Fronteira I
  • Publication Year: 2018
  • Journal: Health Policy
  • Link: https://www.sciencedirect.com/science/article/pii/S0168851018302756

Since the creation of the National Health Service (NHS) in Portugal, in 1979, dental care is neither provided nor funded by the NHS. Thus, most dental care is paid through out-of-pocket payments, either by patients themselves or through voluntary health insurance or health subsystems. In 2008 the government created the dental voucher targeting children, pregnant […]
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Are schoolchildren less infected if they have good knowledge about parasitic worms? A case study from rural Côte d’Ivoire

  • Authors: Palmeirim MS, Ouattara M, Essé C, Koffi VA, Assaré RK, Hürlimann E, Coulibaly JT, Diakité NR, Dongo K, Bonfoh B, Utzinger J, N'Goran EK, Raso G
  • Publication Year: 2018
  • Journal: BMC Public Health
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30071839

BACKGROUND: Parasitic worms (helminths) are common infections in low- and middle-income countries. For most helminth species, school-aged children are at highest risk of infection and morbidity, such as impaired cognitive and physical development. Preventive chemotherapy is the current mainstay for helminthiases control. Sanitation improvement and hygiene-related education are important complementary strategies, which act by altering […]
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Low potassium and high sodium intakes: A double health threat to Cape Verdeans

  • Authors: Alves D, Santos Z, Amado M, Craveiro I, Delgado AP, Correia A, Gonçalves L
  • Publication Year: 2018
  • Journal: BMC Public Health
  • Link: https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-018-5911-x

Background Cape Verde presents a high rate of cardiovascular diseases. Low potassium and high sodium intakes are related to cardiovascular diseases. However, studies regarding these two micronutrients continue to be rare in African urban settings. This work aims to estimate potassium and sodium intakes and to analyse the self-reported salt intake by gender and by […]
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Identifying mixed Mycobacterium tuberculosis infections from whole genome sequence data

  • Authors: Sobkowiak B, Glynn JR, Houben RMGJ, Mallard K, Phelan JE, Guerra-Assunção JA, Banda L, Mzembe T, Viveiros M, McNerney R, Parkhill J, Crampin AC, Clark TG
  • Publication Year: 2018
  • Journal: BMC Genomics
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/30107785

Mixed, polyclonal Mycobacterium tuberculosis infection occurs in natural populations. Developing an effective method for detecting such cases is important in measuring the success of treatment and reconstruction of transmission between patients. Using whole genome sequence (WGS) data, we assess two methods for detecting mixed infection: (i) a combination of the number of heterozygous sites and […]
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The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase

  • Authors: Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosère N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Kumar R, Kumar P, Freundlich JS, Brodin P, Ainsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S
  • Publication Year: 2018
  • Journal: Tuberculosis
  • Link: https://www.tuberculosisjournal.com/article/S1472-9792(18)30008-8/pdf

The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was found to have in vitro activity against Mycobacterium tuberculosis (MIC 5 μg/mL). In macromolecular synthesis assays, pyronaridine resulted in a severe decrease in incorporation of 14C-uracil […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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