GHTM

Global Health and Tropical Medicine

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Home / Archives for Hoffmann E

The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase

  • Authors: Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosère N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Kumar R, Kumar P, Freundlich JS, Brodin P, Ainsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S
  • Publication Year: 2018
  • Journal: Tuberculosis
  • Link: https://www.tuberculosisjournal.com/article/S1472-9792(18)30008-8/pdf

The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was found to have in vitro activity against Mycobacterium tuberculosis (MIC 5 μg/mL). In macromolecular synthesis assays, pyronaridine resulted in a severe decrease in incorporation of 14C-uracil […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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