The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase
- Autores: Mori G, Orena BS, Franch C, Mitchenall LA, Godbole AA, Rodrigues L, Aguilar-Pérez C, Zemanová J, Huszár S, Forbak M, Lane TR, Sabbah M, Deboosère N, Frita R, Vandeputte A, Hoffmann E, Russo R, Connell N, Veilleux C, Kumar R, Kumar P, Freundlich JS, Brodin P, Ainsa JA, Nagaraja V, Maxwell A, Mikušová K, Pasca MR, Ekins S
- Ano de Publicação: 2018
- Journal: Tuberculosis
- Link: https://www.tuberculosisjournal.com/article/S1472-9792(18)30008-8/pdf
The search for compounds with biological activity for many diseases is turning increasingly to drug repurposing. In this study, we have focused on the European Union-approved antimalarial pyronaridine which was found to have in vitro activity against Mycobacterium tuberculosis (MIC 5 μg/mL). In macromolecular synthesis assays, pyronaridine resulted in a severe decrease in incorporation of 14C-uracil […]
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