GHTM

Global Health and Tropical Medicine

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Home / Archives for 2013

Treatment of plasmodium chabaudi parasites with curcumin in combination with antimalarial drugs: Drug interactions and implications on the ubiquitin/proteasome system

  • Authors: Do Rosário V, Gazarini ML, Lindeza A, Lopes D, Machado M, Neto Z
  • Publication Year: 2013
  • Journal: Journal of Parasitology Research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23691276

Antimalarial drug resistance remains a major obstacle in malaria control. Evidence from Southeast Asia shows that resistance to artemisinin combination therapy (ACT) is inevitable. Ethnopharmacological studies have confirmed the efficacy of curcumin against Plasmodium spp.
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Analysis of HIV/AIDS DRG in Portugal: a Hierarchical Finite Mixture Model

  • Authors: Andreozzi V, Dias SS, Martins MO
  • Publication Year: 2013
  • Journal: The European Journal of Health Economics
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/22864565

Inpatient length of stay (LOS) is an important measure of hospital activity, but its empirical distribution is often positively skewed, representing a challenge for statistical analysis. Taking this feature into account, we seek to identify factors that are associated with HIV/AIDS through a hierarchical finite mixture model. A mixture of normal components is applied to adult HIV/AIDS diagnosis-related group data (DRG) from 2008.
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Gender differences in HIV disease progression and treatment outcomes among HIV patients one year after starting antiretroviral treatment (ART) in Dar es Salaam, Tanzania

  • Authors: Lyamuya E, Matee M, Mosha F, Muchunguzi V, Nsubuga P, Sangeda RZ, Vandamme AM, Vercauteren J
  • Publication Year: 2013
  • Journal: BMC Public Health
  • Link: http://www.biomedcentral.com/1471-2458/13/38

We investigated gender differences in treatment outcome during first line antiretroviral treatment (ART) in a hospital setting in Tanzania, assessing clinical, social demographic, virological and immunological factors.
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Trypanosoma cruzi I and IV Stocks from Brazilian Amazon Are Divergent in Terms of Biological and Medical Properties in Mice

  • Authors: Bahia MT, de Araújo SM, de Oliveira Guerra JA, dos Reis D, Gomes ML, Gruendling AP, Magalhaes LK, Margioto Teston AP, Monteiro WM, Silveira H, Toledo MJ, Vale Barbosa Md
  • Publication Year: 2013
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002069

In the Brazilian Amazon, clinical and epidemiological frameworks of Chagas disease are very dissimilar in relation to the endemic classical areas of transmission, possibly due to genetic and biological characteristics of the circulating Trypanosoma cruzi stocks. Twenty six T. cruzi stocks from Western Amazon Region attributed to the TcI and TcIV DTUs were comparatively studied in Swiss mice to test the hypothesis that T. cruzi clonal structure has a major impact on its biological and medical properties.
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Identification and functional characterization of CRK12:CYC9, a novel cyclin-dependent kinase (CDK)-cyclin complex in Trypanosoma brucei

  • Authors: Benz C, Burchmore R, Costa CIA, Forkert A, Hamilton A, Hammarton TC, Monnerat S, Mottram JC, Novo C, Tetley L
  • Publication Year: 2013
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067327

The protozoan parasite, Trypanosoma brucei, is spread by the tsetse fly and causes trypanosomiasis in humans and animals. Both the life cycle and cell cycle of the parasite are complex. Trypanosomes have eleven cdc2-related kinases (CRKs) and ten cyclins, an unusually large number for a single celled organism. To date, relatively little is known about the function of many of the CRKs and cyclins, and only CRK3 has previously been shown to be cyclin-dependent in vivo.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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