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Home / Archives for Silveira H

Trypanosoma cruzi strain Tcl is associated with chronic Chagas disease in the Brazilian Amazon

  • Authors: Barbosa MDV, Barbosa-Ferreira JM, Coelho LI, da Silva GA, de Brito FR, Guerra JAO, Maciel MG, Magalhaes LK, Magalhaes LKC, Monteiro WM, Prestes SR, Santana RAG, Silveira H
  • Publication Year: 2014
  • Journal: Parasites & Vectors
  • Link: http://www.parasitesandvectors.com/content/7/1/267

The aim of this study was to characterize Trypanosoma cruzi in patients with chronic Chagas disease in the State of Amazonas, Brazil.
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Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion

  • Authors: Custodio A, Ramos S, Silveira H
  • Publication Year: 2014
  • Journal: Memórias do Instituto Oswaldo Cruz
  • Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156460/

Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown. Plasmodium berghei-infected mosquitoes were injected with an eicosanoid biosynthesis inhibitor, indomethacin (IN), or a substrate, arachidonic acid (AA), at day 7 or day 12 post-infection (p.i.).
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Mosquito Akirin as a potential antigen for malaria control

  • Authors: Costa M, Custodio, de la Fuente J, Domingos A, Moreno-Cid JA, Pinheiro-Silva R, Silveira H, Villar M
  • Publication Year: 2014
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/13/1/470

Recent evidences using Subolesin (SUB) and Akirin (AKR) vaccines showed a reduction in the survival and/or fertility of blood-sucking ectoparasite vectors and the infection with vector-borne pathogens. These experiments suggested the possibility of using AKR for malaria control.
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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