Appearance of a single amino acid insertion at position 33 in HIV type 1 protease under a lopinavir-containing regimen, associated with reduced protease inhibitor susceptibility.

• Authors: Camacho RJ, Detsika MG, Hatzakis A, Imbrechts S, Lazanas M, Lu L, Magiorkinis E, Magiorkinis G, Molla A, Paraskevis D, Pilot-Matias T, Van Laethem K, Vandamme AM
• Journal: AIDS Research and Human Retroviruses
• Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Appearance+of+a+Single+Amino+Acid+Insertion+at+Position+33+in+HIV+Type+1+Protease+Under+a+Lopinavir-Containing+Regimen%2C+Associated+with+Reduced+Protease+Inhibitor+Susceptibility

HIV drug resistance is a multifactorial phenomenon and constitutes a major concern as it results in therapy failure. The aim of this study was to assess the impact of an amino acid insertion identified at position 33 of the protease gene, derived from samples from three patients under lopinavir therapy, on viral fitness and protease inhibitor (PI) resistance.
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