GHTM

Global Health and Tropical Medicine

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Activity of rifabutin and hemi-synthetic derivatives against Mycobacterium abscessus

BACKGROUND: Mycobacterium abscessus causes a wide range of clinical diseases that are difficult to treat. This microorganism is resistant not only to the classical antituberculosis agents but also to most of the antimicrobials that are currently available, resulting in limited therapeutic options and treatment failure. This scenario stresses the need to search for new drugs […]
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Genetic diversity of the African malaria vector Anopheles gambiae

The sustainability of malaria control in Africa is threatened by the rise of insecticide resistance in Anopheles mosquitoes that transmit the disease1. To gain a deeper understanding of how mosquito populations are evolving, we sequenced the genomes of 765 specimens of Anopheles gambiae and Anopheles coluzzii sampled from 15 locations across Africa, identifying over 50 million single nucleotide polymorphisms within the […]
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The use of a methodological framework in the implementation of evidence as part of nursing research

OBJECTIVE: to reflect on the potentials of the conceptual framework Promoting Action on Research Implementation in Health Services (PARIHS) to translate knowledge and implement evidences in health and nursing. METHOD: this reflection was based on the methodological framework proposed, its use in the international context of health and nursing research and the possibilities in the Brazilian context. […]
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The effects of austerity measures on quality of healthcare services: A national survey of physicians in the public and private sectors in Portugal

Background The European Union member countries reacted differently to the 2008 economic and financial crisis. However, few countries have monitored the outcomes of their policy responses, and there is therefore little evidence as to whether or not savings undermined the performance of health systems. We discuss the situation in Portugal, where a financial adjustment program […]
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Phylogenetic analysis as a forensic tool in HIV transmission investigations

HIV Phylogenetic analysis: a literature review The authors performed a literature review to analyse HIV phylogenetic analyses methods as a forensic tool. Because HIV is a fast-evolving virus, HIV genomic sequences of several individuals can be used to investigate whether they belong to a transmission network. Since the infamous ‘Florida dentist case’ in the beginning […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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Rua da Junqueira, 100
1349-008 Lisboa
Portugal

+351 213 652 600

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