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Global Health and Tropical Medicine

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Home / Archives for vol 11

Wide and increasing suitability for Aedes albopictus in Europe is congruent across distribution models

  • Autores: Sandra Oliveira, Jorge Rocha, Carla A. Sousa, César Capinha
  • Ano de Publicação: 2021
  • Journal: Scientific Reports, vol 11, art 9916
  • Link: https://doi.org/10.1038/s41598-021-89096-5

ABSTRACT The Asian tiger mosquito (Aedes albopictus), a vector of dengue, Zika and other diseases, was introduced in Europe in the 1970s, where it is still widening its range. Spurred by public health concerns, several studies have delivered predictions of the current and future distribution of the species for this region, often with differing results. […]
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Insights of antiparasitic activity of sodium diethyldithiocarbamate against different strains of Trypanosoma cruzi

  • Autores: Johny Wysllas de Freitas Oliveira, Taffarel Melo Torres, Cláudia Jassica Gonçalves Moreno, Bruno Amorim-Carmo, Igor Zumba Damasceno, Ana Katarina Menezes Cruz Soares, Jefferson da Silva Barbosa, Hugo Alexandre Oliveira Rocha, Marcelo Sousa-Silva
  • Ano de Publicação: 2021
  • Journal: Scientific Reports, vol 11, art 11200
  • Link: https://doi.org/10.1038/s41598-021-90719-0

ABSTRACT Chagas disease is caused by Trypanosoma cruzi and affects thousands of people. Drugs currently used in therapy are toxic and have therapeutic limitations. In addition, the genetic diversity of T. cruzi represents an important variable and challenge in treatment. Sodium diethyldithiocarbamate (DETC) is a compound with pharmacological versatility acting as metal chelators and ROS generation. Thus, the objective […]
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Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodomain contributes to reduce viral burden in HIV-1 infected patients

  • Autores: Rute Marcelino, Filipa Gramacho, Francisco Martin, Pedro Brogueira, Nuno Janeiro, Claudia Afonso, Robert Badura, Emília Valadas, Kamal Mansinho, Luís Caldeira, Nuno Taveira, José M. Marcelino
  • Ano de Publicação: 2021
  • Journal: Scientific Reports, vol 11, art 8993
  • Link: https://doi.org/10.1038/s41598-021-88274-9

ABSTRACT The ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located in the gp41 ectodomain may be potential HIV vaccine candidates. We assessed 3S- and EC26-specific binding […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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