GHTM

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Home / Archives for Scientific Reports

Origin and expansion of the mosquito Aedes aegypti in Madeira Island (Portugal)

  • Authors: Seixas G, Salgueiro P, Bronzato-Badial A, Gonçalves Y, Reyes-Lugo M, Viveiros B, Gordicho V, Ribolla P, Silva AC, Pinto J, Sousa CA
  • Publication Year: 2019
  • Journal: Scientific Reports
  • Link: https://www.nature.com/articles/s41598-018-38373-x

Historically known as the yellow fever mosquito, Aedes aegypti invaded Madeira Island in 2005 and was the vector of the island’s first dengue outbreak in 2012. We have studied genetic variation at 16 microsatellites and two mitochondrial DNA genes in temporal samples of Madeira Island, in order to assess the origin of the invasion and the population […]
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Anopheline antiplatelet protein from mosquito saliva regulates blood feeding behavior

  • Authors: Islam A, Emran TB, Yamamoto DS, Iyori M, Amelia F, Yusuf Y, Yamaguchi R, Alam MDS, Silveira H, Yoshida S
  • Publication Year: 2019
  • Journal: Scientific Reports
  • Link: https://www.nature.com/articles/s41598-019-39960-2

The saliva of hematophagous arthropods is enriched with a complex mixture of antihemostatic molecules, the biological functions of which are largely unknown. Anopheline antiplatelet protein (AAPP) from malaria vector mosquito exhibits strong antiplatelet activity when bound directly to host collagen by its C-terminus and through its N-terminus with Ca2+-binding activity. To investigate the biological functions […]
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Making a meal of it: Mosquito spit protein controls blood feeding

  • Authors: Islam A, Emran TB, Yamamoto DS, Iyori M, Amelia F, Yusuf Y, Yamaguchi R, Alam MDS, Silveira H, Yoshida S
  • Publication Year: 2019
  • Journal: Scientific Reports
  • Link: https://www.sciencedaily.com/releases/2019/05/190510102932.htm

A Japan-based research team led by Kanazawa University used the most up-to-date simulation techniques to determine how to make Researchers led by Kanazawa University developed a transgenic approach to inactivating the mosquito salivary protein AAPP. Transgenic mosquitos showed significantly longer probing and prediuresis times, and worse feeding success and meal sizes compared with their wild-type […]
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Fresh-blood-free diet for rearing malaria mosquito vectors

  • Authors: Cardoso JCR, Felix RC, Guerra MGB, Marques J, Power D, Santana RAG, Silveira H
  • Publication Year: 2018
  • Journal: Scientific Reports
  • Link: https://www.nature.com/articles/s41598-018-35886-3

Mosquito breeding depends on the supply of fresh vertebrate blood, a major bottleneck for large-scale production of Anopheles spp. Feeding alternatives to fresh blood are thus a priority for research, outdoor large-cage trials and control interventions. Several artificial meal compositions were tested and Anopheles oogenesis, egg laying and development into the next generation of adult mosquitoes were followed. We […]
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Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glycans terminated by alpha-2–6 sialic acids

  • Authors: Loureiro LR, Sousa DP, Ferreira D, Chai W, Lima L, Pereira C, Lopes CB, Correia VG, Silva LM, Li C, Santos LL, Ferreira JA, Barbas A, Palma AS, Novo C, Videira PA
  • Publication Year: 2018
  • Journal: Scientific Reports
  • Link: https://www.nature.com/articles/s41598-018-30421-w

Incomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities and cross-reactivity. In this study, a novel anti-STn monoclonal antibody named L2A5 was developed by hybridoma […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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