Adjuvant therapies against tuberculosis: Discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics
- Authors: Machado D, Azzali E, Couto I, Costantino G, Pieroni M, Viveiros M
- Publication Year: 2018
- Journal: Future Microbiology
- Link: https://www.futuremedicine.com/doi/10.2217/fmb-2018-0110
AIM: To evaluate the activity of the 2-aminothiazole UPAR-174 following an unexplored approach: targeting Mycobacterium tuberculosis with lipophilic compounds that present antituberculosis and efflux inhibitory activity. METHODS: Antituberculosis activity was assessed against replicating, nonreplicating and intracellular bacilli. Its capacity to inhibit active efflux was determined. ATP quantification and membrane potential analysis were performed. Intracellular activity […]
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