Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort
- Autores: Abecasis AB, Assel M, Bartha I, Luca AD, Müller V, Paredes R, Rosi A, Schülter E, Sloot PMA, Sönner-borg A, Svärd J, Torti C, van de Vijver DC, Van Laethem K, Vandamme AM, Zazzi M
- Ano de Publicação: 2013
- Journal: BMC Infectious Diseases
- Link: http://www.biomedcentral.com/1471-2334/13/537/
Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.