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Global Health and Tropical Medicine

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Control of Vector-Borne Human Parasitic Diseases

Vector-borne diseases (VBD) transmitted by arthropods are responsible for over 1 billion cases and 1 million deaths every year, corresponding to at least 17% of all infectious diseases in human populations [1]. Among them, we can find malaria, leishmaniasis, onchocerciasis, lymphatic filariasis, Chagas disease, and African trypanosomiases, as well as several arboviral diseases (arthropod-borne virus) […]
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Plasmodium falciparum genetic diversity in continental Equatorial Guinea before and after introduction of artemisinin based combination therapy

Efforts to control malaria may affect malaria parasite genetic variability and drug resistance, the latter of which is associated with genetic events that promote mechanisms to escape drug action. The worldwide spread of drug resistance has been a major obstacle to controlling Plasmodium falciparum malaria, and thus the study of the origin and spread of associated mutations […]
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Population diversity of Theileria annulata in Portugal

The tick-borne protozoan parasite Theileria annulata causes tropical theileriosis, a severe disease of cattle that occurs across the Mediterranean littoral, the Middle East and Southern Asia. In the Mediterranean region, the disease has long been perceived as being a constraint to livestock production in North Africa and Turkey but was believed to have minimal impact […]
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Genetic diversity and population structure of Plasmodium falciparum over space and time in an African archipelago

The archipelago of São Tomé and Principe (STP), West Africa, has suffered the heavy burden of malaria since the 16th century. Until the last decade, when after a successful control program STP has become a low transmission country and one of the few nations with decreases of more than 90% in malaria admission and death […]
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Molecular evolution and population genetics of a Gram-negative binding protein gene in the malaria vector Anopheles gambiae (sensu lato)

Background Clarifying the role of the innate immune system of the malaria vector Anopheles gambiae is a potential way to block the development of the Plasmodium parasites. Pathogen recognition is the first step of innate immune response, where pattern recognition proteins like GNBPs play a central role. Results We analysed 70 sequences of the protein coding gene GNBPB2 from two species, Anopheles […]
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GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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