Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype
- Authors: Coelho L, Lukens AK, Mazitschek R, Moreira R, Nogueira F, Paulo A, Santos SA, Wirth DF
- Publication Year: 2015
- Journal: Journal of Medicinal Chemistry
- Link: http://www.ncbi.nlm.nih.gov/pubmed/26295174
A series of 3-piperidin-4-yl-1H-indoles with building block diversity was synthesized based on a hit derived from an HTS whole-cell screen against Plasmodium falciparum. Thirty-eight compounds were obtained following a three-step synthetic approach and evaluated for anti-parasitic activity.
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