GHTM

Global Health and Tropical Medicine

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Hepatitis delta: In vitro evaluation of cytotoxicity and cytokines involved in PEG-IFN therapy

HIGHLIGHTS • HBsAg and SHDAg display toxicity in co-cultured cells (Jurkat + THP-1). • PEG-IFN reduces cytotoxicity profile and increases IL-12, IL-2 and IFN-γ production. • PEG-IFN restores the production of IFN-γ by SHDAg-stimulated cells. ABSTRACT The treatment for hepatitis Delta virus (HDV) still consists of Pegylated interferon (PEG-IFN) combined with inhibitors of Hepatitis B […]
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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1349-008 Lisboa
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+351 213 652 600

Funding

UID/04413/2025 - DOI: 10.54499/UID/04413/2025

UID/PRR/04413/2025 - DOI: 10.54499/UID/PRR/04413/2025

UID/PRR2/04413/2025 - DOI: 10.54499/UID/PRR2/04413/2025