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Home / Archives for Dimas Tadeu Covas

Hepatitis delta: In vitro evaluation of cytotoxicity and cytokines involved in PEG-IFN therapy

  • Autores: Larissa Deadame de Figueiredo Nicolete, Celso Vladimiro Cunha, João Paulo Tavanez, Mariana Tomazini Pinto, Evandra Strazza Rodrigues, Simone Kashima, Dimas Tadeu Covas, Juan Miguel Villalobos-Salcedo, Roberto Nicolete
  • Ano de Publicação: 2021
  • Journal: International Immunopharmacology, vol 91, art 107302
  • Link: https://doi.org/10.1016/j.intimp.2020.107302

HIGHLIGHTS • HBsAg and SHDAg display toxicity in co-cultured cells (Jurkat + THP-1). • PEG-IFN reduces cytotoxicity profile and increases IL-12, IL-2 and IFN-γ production. • PEG-IFN restores the production of IFN-γ by SHDAg-stimulated cells. ABSTRACT The treatment for hepatitis Delta virus (HDV) still consists of Pegylated interferon (PEG-IFN) combined with inhibitors of Hepatitis B […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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