Hepatitis delta: In vitro evaluation of cytotoxicity and cytokines involved in PEG-IFN therapy
- Autores: Larissa Deadame de Figueiredo Nicolete, Celso Vladimiro Cunha, João Paulo Tavanez, Mariana Tomazini Pinto, Evandra Strazza Rodrigues, Simone Kashima, Dimas Tadeu Covas, Juan Miguel Villalobos-Salcedo, Roberto Nicolete
- Ano de Publicação: 2021
- Journal: International Immunopharmacology, vol 91, art 107302
- Link: https://doi.org/10.1016/j.intimp.2020.107302
HIGHLIGHTS • HBsAg and SHDAg display toxicity in co-cultured cells (Jurkat + THP-1). • PEG-IFN reduces cytotoxicity profile and increases IL-12, IL-2 and IFN-γ production. • PEG-IFN restores the production of IFN-γ by SHDAg-stimulated cells. ABSTRACT The treatment for hepatitis Delta virus (HDV) still consists of Pegylated interferon (PEG-IFN) combined with inhibitors of Hepatitis B […]
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