Pharmacogene sequencing of a gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment
- Authors: Leyre Pernaute-Lau, Ayola Akim Adegnika, Yitian Zhou, Jeannot F Zinsou, Jose Pedro Gil, Sanjeev Krishna, Peter G Kremsner, Volker M Lauschke, Thirumalaisamy P Velavan
- Publication Year: 2021
- Journal: Antimicrobial Agents and Chemotherapy, 65(7), art e00275-21
- Link: https://doi.org/10.1128/AAC.00275-21
ABSTRACT Malaria remains one of the deadliest diseases in Africa, particularly for children. While successful in reducing morbidity and mortality, antimalarial treatments are also a major cause of adverse drug reactions (ADRs). Host genetic variation in genes involved in drug disposition or toxicity constitutes an important determinant of ADR risk and can prime for parasite […]
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