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Home / Archives for Jose Pedro Gil

Pharmacogene sequencing of a gabonese population with severe Plasmodium falciparum malaria reveals multiple novel variants with putative relevance for antimalarial treatment

  • Autores: Leyre Pernaute-Lau, Ayola Akim Adegnika, Yitian Zhou, Jeannot F Zinsou, Jose Pedro Gil, Sanjeev Krishna, Peter G Kremsner, Volker M Lauschke, Thirumalaisamy P Velavan
  • Ano de Publicação: 2021
  • Journal: Antimicrobial Agents and Chemotherapy, 65(7), art e00275-21
  • Link: https://doi.org/10.1128/AAC.00275-21

ABSTRACT Malaria remains one of the deadliest diseases in Africa, particularly for children. While successful in reducing morbidity and mortality, antimalarial treatments are also a major cause of adverse drug reactions (ADRs). Host genetic variation in genes involved in drug disposition or toxicity constitutes an important determinant of ADR risk and can prime for parasite […]
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Influence of cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate‐amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

  • Ano de Publicação: 2021
  • Journal: Malaria Journal, vol 20, art 90
  • Link: https://doi.org/10.1186/s12936-021-03620-6

ABSTRACT ‘Background:’ The anti-malarial drug, amodiaquine, a commonly used, long-acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8). The CYP2C8 gene carries several polymorphisms including the more frequent minor alleles, CYP2C8*2 and CYP2C8*3. These minor alleles have been associated with decreased enzymatic activity, slowing the amodiaquine biotransformation towards DEAQ. This study […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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