Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review

Authors: Cruz LA, Lago JHG, Laurenti MD, Passero LFD, Rodrigues E, Santos-Gomes G
Publication Year: 2018
Journal: Current Topics in Medicinal Chemistry
Link: https://www.ncbi.nlm.nih.gov/pubmed/30277153

Leishmaniasis is a neglected disease caused by protozoan belonging to the Leishmania genus. There are at least 16 pathogenic species for humans that are able to cause different clinical forms, such as cutaneous or visceral leishmaniasis. In spite of the different species and clinical forms, the treatment is performed with few drug options that, in […]
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Report of in vitro antileishmanial properties of Iberian macroalgae

Authors: Bruno de Sousa C, Lago JHG, Macridachis J, Oliveira M, Brito L, Vizetto-Duarte C, Florindo C, Hendrickx S, Maes L, Morais T, Uemi M, Neto L, Dionísio L, Cortes S, Barreira L, Custódio L, Alberício F, Campino L, Varela J
Publication Year: 2018
Journal: Natural Product Research
Link: https://www.tandfonline.com/doi/full/10.1080/14786419.2018.1434637

ere is reported the anti Leishmania infantum activity of 48 hexane, CH2Cl2 and MeOH extracts from 16 macroalgae collected on the Iberian Coast. Seven hexane and CH2Cl2 Cystoseira baccata, Cystoseira barbata, Cystoseira tamariscifolia, Cystoseira usneoides, Dictyota spiralis and Plocamium cartilagineum extracts were active towards promastigotes (IC50 29.8–101.8 μg/mL) inducing strong morphological alterations in the parasites. Hexane extracts of C. […]
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Corrigendum to “Therapeutic effect of ursolic acid in experimental visceral leishmaniasis”

Authors: Ferreira AF, Fragoso TN, Jesus JA, Lago JHG, Laurenti MD, Passero LFD, Santos-Gomes G, Silva MS, Yamamoto ES
Publication Year: 2017
Journal: International Journal for Parasitology: Drugs and Drug Resistance
Link: https://www.sciencedirect.com/science/article/pii/S2211320716300860

Leishmaniasis is an important neglected tropical disease, affecting more than 12 million people worldwide. The available treatments are not well tolerated and present diverse side effects in patients, justifying the search for new therapeutic compounds. In the present study, the therapeutic potential and toxicity of ursolic acid (UA), isolated from the leaves of Baccharis uncinella C. DC. […]
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Conventional Versus Natural Alternative Treatments for Leishmaniasis: A Review

Report of in vitro antileishmanial properties of Iberian macroalgae

Corrigendum to “Therapeutic effect of ursolic acid in experimental visceral leishmaniasis”

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