Genomewide Scan Reveals Amplification of mdr1 as a Common Denominator of Resistance to Mefloquine, Lumefantrine, and Artemisinin in Plasmodium chabaudi Malaria Parasites
- Autores: Borges S, Cravo P, Creasey A, Fawcett R, Hunt P, Martinelli A, Modrzynska K, Rodrigues L
- Journal: Antimicrobial Agents and Chemotherapy
- Link: https://www.ncbi.nlm.nih.gov/pubmed/21709099
Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs). Here we used linkage group selection and Solexa whole-genome resequencing to investigate the genetic basis of resistance to component drugs of ACTs.
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