Molecular epidemiology and host genetics of norovirus and rotavirus infections in Portuguese elderly living in aged care homes

Authors: Piedade J, Nordgren J, Esteves F, Esteves A, Teodósio R, Svensson L, Istrate C
Publication Year: 2019
Journal: Journal of Medical Virology
Link: https://www.ncbi.nlm.nih.gov/pubmed/30735247

Norovirus (NoV) and rotavirus group A (RVA) are major agents of acute gastroenteritis worldwide. This study aimed to investigate their epidemiological profile in Portuguese elderly living in long-term care facilities and to assess the host genetic factors mediating infection susceptibility. From November 2013 to June 2015, 636 faecal specimens from 169 elderly, mainly asymptomatic, living […]
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Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting.

Authors: Ahlman H, Buesa J, Engblom D, Hagbom M, Istrate C, Karlsson T, Loitto VM, Lundgren O, Magnusson KE, Rodriguez-Diaz J, Svensson L, Taylor JA
Journal: PLoS Pathogens
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Rotavirus+stimulates+release+of+serotonin+(5-HT)+from+human+enterochromaffin+cells+and+activates+brain+structures+involved+in+nausea+and+vomiting

Rotavirus (RV) is the major cause of severe gastroenteritis in young children. A virus-encoded enterotoxin, NSP4 is proposed to play a major role in causing RV diarrhoea but how RV can induce emesis, a hallmark of the illness, remains unresolved.
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Rotavirus infection increases intestinal motility but not permeability at the onset of diarrhea

Authors: Hagbom M, Istrate C, Magnusson KE, Svensson L, Vikstrom E
Publication Year: 2014
Journal: Journal of Virology
Link: http://www.ncbi.nlm.nih.gov/pubmed/24371070

The disease mechanisms associated with onset and secondary effects of rotavirus (RV) diarrhea remain to be determined and may not be identical. In this study, we investigated whether onset of RV diarrhea is associated with increased intestinal permeability and/or motility. To study the transit time, fluorescent fluorescein isothiocyanate (FITC)-dextran was given to RV-infected adult and infant mice. Intestinal motility was also studied with an opioid receptor agonist (loperamide) and a muscarinic receptor antagonist (atropine)
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Molecular epidemiology and host genetics of norovirus and rotavirus infections in Portuguese elderly living in aged care homes

Rotavirus stimulates release of serotonin (5-HT) from human enterochromaffin cells and activates brain structures involved in nausea and vomiting.

Rotavirus infection increases intestinal motility but not permeability at the onset of diarrhea

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