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Home / Archives for Vikstrom E

Rotavirus infection increases intestinal motility but not permeability at the onset of diarrhea

  • Authors: Hagbom M, Istrate C, Magnusson KE, Svensson L, Vikstrom E
  • Publication Year: 2014
  • Journal: Journal of Virology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24371070

The disease mechanisms associated with onset and secondary effects of rotavirus (RV) diarrhea remain to be determined and may not be identical. In this study, we investigated whether onset of RV diarrhea is associated with increased intestinal permeability and/or motility. To study the transit time, fluorescent fluorescein isothiocyanate (FITC)-dextran was given to RV-infected adult and infant mice. Intestinal motility was also studied with an opioid receptor agonist (loperamide) and a muscarinic receptor antagonist (atropine)
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About GHTM

GHTM is a R&D Unit that brings together researchers with a track record in Tropical Medicine and International & Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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