Animal models of depression and drug delivery with food as an effective dosing method: Evidences from studies with celecoxib and dicholine succinate
- Autores: Araújo-Correia M, Cline BH, Costa-Nunes JP, Dolgov O, Kubatiev A, Markova N, Steinbusch HW, Strekalova T, Valença A, Yeritsyan N
- Ano de Publicação: 2015
- Journal: BioMed Research International
- Link: https://www.hindawi.com/journals/bmri/2015/596126/%20
Multiple models of human neuropsychiatric pathologies have been generated during the last decades which frequently use chronic dosing. Unfortunately, some drug administration methods may result in undesirable effects creating analysis confounds hampering model validity and preclinical assay outcomes. Here, automated analysis of floating behaviour, a sign of a depressive-like state, revealed that mice, subjected to […]
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