GHTM

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Home / Archives for Dolgov O

Animal models of depression and drug delivery with food as an effective dosing method: Evidences from studies with celecoxib and dicholine succinate

  • Autores: Araújo-Correia M, Cline BH, Costa-Nunes JP, Dolgov O, Kubatiev A, Markova N, Steinbusch HW, Strekalova T, Valença A, Yeritsyan N
  • Ano de Publicação: 2015
  • Journal: BioMed Research International
  • Link: https://www.hindawi.com/journals/bmri/2015/596126/%20

Multiple models of human neuropsychiatric pathologies have been generated during the last decades which frequently use chronic dosing. Unfortunately, some drug administration methods may result in undesirable effects creating analysis confounds hampering model validity and preclinical assay outcomes. Here, automated analysis of floating behaviour, a sign of a depressive-like state, revealed that mice, subjected to […]
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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