In silico and in vitro evaluation of tetrahydropyridine compounds as efflux inhibitors in Mycobacterium abscessus

• Authors: Ramis IB, Vianna JS, Silva Junior L, von Groll A, Ramos DF, Zanatta N, Viveiros M, Silva PEAD
• Publication Year: 2019
• Journal: Tuberculosis
• Link: https://www.sciencedirect.com/science/article/pii/S1472979219300654

Herein, we evaluated tetrahydropyridine (THP) compounds (NUNM) as antimicrobials and inhibitors of the efflux mechanism in M. abscessus. subsp. abscessus. The modulation factor (MF) of efflux inhibitors was calculated from the minimum inhibitory concentrations (MICs) of amikacin (AMI), ciprofloxacin (CIP) and clarithromycin (CLA) in the absence and presence of subinhibitory concentrations of the NUNM compounds and canonical […]
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