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Home / Archives for Radfar A

Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant strains

  • Autores: Bautista JM, Diez A, Do Rosário VE, Nogueira F, Pérez-Benavente S, Puyet A, Radfar A
  • Journal: Acta Tropica
  • Link: http://www.pubpdf.com/pub/20138820/Early-transcriptional-response-to-chloroquine-of-the-Plasmodium-falciparum-antioxidant-defence-in-se

Resistance to chloroquine (CQ) in Plasmodium falciparum has a major impact on malaria control worldwide. To gain insight into early parasite stress response, mRNA expression profiles were determined for a set of 10 antioxidant defence genes in synchronized CQ-sensitive (3D7) and CQ-resistant (Dd2) clones under transient IC50 CQ-exposure (Dd2, 200 nM; 3D7, 14 nM). Upon 2-h CQ challenge, the mRNA upregulation detected was greater in 3D7 (six genes overexpressed at 1/3 of the intraerythrocytic cycle) than in Dd2 clone (three genes responding), providing evidence of an early transcriptional response to CQ-induced oxidative stress which might underlie some of the parasite’s metabolic adaptation to the drug.
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GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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