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Home / Archives for Martins TM

Expression and characterization of the Babesia bigemina cysteine protease BbiCPL1

  • Autores: Martins TM, Do Rosário VE, Domingos A
  • Journal: Acta Tropica
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Expression+and+characterization+of+the+Babesia+bigemina+cysteine+protease+BbiCPL1.

BbiCPL1 was the first papain-like cysteine protease from a piroplasm to be identified with proteolytic activity. Here we report the improved production of the active recombinant enzyme, and the biochemical characterization of this potential drug target.
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Identification of papain-like cysteine proteases from the bovine piroplasm Babesia bigemina and evolutionary relationship of piroplasms C1 family of cysteine proteases.

  • Autores: Do Rosário VE, Martins TM
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+papain-like+cysteine+proteases+from+the+bovine+piroplasm+Babesia+bigemina+and+evolutionary+relationship+of+piroplasms+C1+family+of+cysteine+proteases.

Papain-like cysteine proteases have been shown to have essential roles in parasitic protozoa and are under study as promising drug targets. Five genes were identified by sequence similarity search to be homologous to the cysteine protease family in the ongoing Babesia bigemina genome sequencing project database and were compared with the annotated genes from the complete bovine piroplasm genomes of Babesia bovis, Theileria annulata, and Theileria parva.
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Expression and characterization of the Babesia bigemina cysteine protease BbiCPL1.

  • Autores: Martins TM, Do Rosário VE, Domingos A
  • Journal: Acta Tropica
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Expression+and+characterization+of+the+Babesia+bigemina+cysteine+protease+babesipain-1.

BbiCPL1 was the first papain-like cysteine protease from a piroplasm to be identified with proteolytic activity. Here we report the improved production of the active recombinant enzyme, and the biochemical characterization of this potential drug target.
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Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterization, expression and in silico modelling.

  • Autores: Cortes H, Hemphill A, Leitão A, Marcelino E, Martins TM, Morais JB, Nolasco S, Novo C
  • Journal: The Electronic Journal Information Systems Evaluation
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Besnoitia+besnoiti+protein+disulfide+isomerase+(BbPDI)%3A+molecular+characterization%2C+expression+and+in+silico+modelling

Besnoitia besnoiti is an apicomplexan parasite responsible for bovine besnoitiosis, a disease with a high prevalence in tropical and subtropical regions and re-emerging in Europe. Despite the great economical losses associated with besnoitiosis, this disease has been underestimated and poorly studied, and neither an effective therapy nor an efficacious vaccine is available.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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