Challenging the drug-likeness dogma for new drug discovery in Tuberculosis
- Authors: Machado D, Girardini M, Viveiros M, Pieroni M
- Publication Year: 2018
- Journal: Frontiers in Microbiology
- Link: https://www.ncbi.nlm.nih.gov/pubmed/30018597
The emergence of multi- and extensively drug resistant tuberculosis worldwide poses a great threat to human health and highlight the need to discover and develop new, effective and inexpensive antituberculosis agents. High-throughput screening assays against well-validated drug targets and structure based drug design have been employed to discover new lead compounds. However, the great majority […]
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