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Home / Archives for Collins LV

CpG-containing oligodeoxynucleotides increases resistance of Anopheles mosquitoes to Plasmodium infection.

  • Autores: Collins LV, Custodio A, Felix R, Gabriel A, Palma J, Ramos S, Silveira H
  • Journal: Insect Biochemistry and Molecular Biology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=CpG-containing+oligodeoxynucleotides+increases+resistance+of+Anopheles+mosquitoes+to+Plasmodium+infection

Unmethylated CpG dinucleotide motifs in bacterial DNA or in synthetic oligodeoxynucleotides (ODN) are potent stimulators of the vertebrate innate immune system. However, the potential of these DNA species to modulate mosquito immunity have not been explored. In the present study, we investigated the effects of CpG-ODN on the outcome of Plasmodium infection in insects and on the modulation of mosquito immunity to Plasmodium.
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About GHTM

GHTM is a R&D Center that brings together researchers from IHMT with a track record in Tropical Medicine and International/Global Health. It aims at strengthening Portugal's role as a leading partner in the development and implementation of a global health research agenda. Our evidence-based interventions contribute to the promotion of equity in health and to improve the health of populations.

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