CpG-containing oligodeoxynucleotides increases resistance of Anopheles mosquitoes to Plasmodium infection.
- Autores: Collins LV, Custodio A, Felix R, Gabriel A, Palma J, Ramos S, Silveira H
- Journal: Insect Biochemistry and Molecular Biology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=CpG-containing+oligodeoxynucleotides+increases+resistance+of+Anopheles+mosquitoes+to+Plasmodium+infection
Unmethylated CpG dinucleotide motifs in bacterial DNA or in synthetic oligodeoxynucleotides (ODN) are potent stimulators of the vertebrate innate immune system. However, the potential of these DNA species to modulate mosquito immunity have not been explored. In the present study, we investigated the effects of CpG-ODN on the outcome of Plasmodium infection in insects and on the modulation of mosquito immunity to Plasmodium.